Now this, is truly amazing. First thing I want to say, is the sketchy lines give a really good effect to the motion of the picture. It makes the fact that he's running look really cool!
The motion of his jacket looks quite wonderful and I can imagine the picture moving, like he is moving towards me. I love his determined yet beautiful emotion on his face, and how he holds Mello's necklace.
You have got the anime anatomy good, and the pose is drawn very well. The only thing I would say you would need to improve on is the sketchy lines on his jeans, there might be a bit too many lines, and his arm looks a bit too bent, but it still looks GREAT! Good job on this artwork!
The colours and the streaks of rain really make it hit home, and the addition of him holding the rosary is great. The lighting makes it look like he's illuminated by car headlights, which is a great effect. The hair looks damp and the arms and hands... are amazing. I for one cannot draw hands, but these look so realistic! I love it so much! The highlights in his hair and on the fur of his weird vest/bodywarmer/jacket make it look amazing.
The rain effect with the drops on the camera look amazing and add to the rain effect. It's so amazing